PROMETHEUS® Monitr™ Crohn's Disease Test

The serum test that gives the mucosa a voice

Measure and monitor mucosal healing status at any time in your Crohn's disease patients with 1 noninvasive test

Measure, monitor, and track mucosal healing status over time in your Crohn's disease (CD) patients with 1 noninvasive test

Mucosal healing provides an objective measure of therapeutic response in Crohn's disease management.1 However, current assessment methods may not provide needed information, particularly when assessing disease activity in difficult-to-reach locations like the small bowel.1-3

The PROMETHEUS® Monitr™ Crohn's Disease Test is a laboratory-developed test that evaluates multiple mucosal damage and repair processes, regardless of disease location.1 It features a proprietary algorithm specific to mucosal healing—and a unique combination of 13 biomarkers—to provide information that cannot be obtained with endoscopy or biopsy to aid in the assessment of mucosal healing.

Comprehensive assessment

Incorporates a panel of biomarkers that are associated with mucosal homeostasis, mucosal damage, and wound healing.4,5

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Quantitative test results

Provides a Mucosal Healing Index Score to distinguish remission-to-mild endoscopic disease from active disease.

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Proven test performance4,6

Monitr has a 90% concordance rate with endoscopically visualized mucosal inflammation.6

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References



*In a study where 748 serum samples from 396 adult Crohn's disease patients were divided into 2 cohorts: 335 samples from 278 patients were used to develop the Mucosal Healing Index (biomarker expression was modeled against endoscopic scoring CDEIS [Crohn’s Disease Endoscopic Index of Severity] or SES-CD [Simple Endoscopic Score for Crohn’s Disease]) and 412 samples from 118 adult Crohn's disease patients were analyzed with endoscopic scoring for independent validation.4

References:

  1. 1.De Cruz P, Kamm MA, Prideaux L, Allen PB, Moore G. Mucosal healing in Crohn's disease: a systematic review. Inflamm Bowel Dis. 2013;19(2):429-444.

  2. 2.Shah SC, Colombel JF, Sands BE, Narula N. Systematic review with meta-analysis: mucosal healing is associated with improved long-term outcomes in Crohn's disease. Aliment Pharmacol Ther. 2016;43(3):317-333.

  3. 3.Bryant RV, Winer S, Travis SP, Riddell RH. Systematic review: histological remission in inflammatory bowel disease. Is ‘complete' remission the new treatment paradigm? An IOIBD initiative. J Crohns Colitis. 2014;8(12):1582-1597.

  4. 4.Vermeire S, D'Haens G, Hale M, et al. A novel serum test to describe the mucosal healing state by disease location in Crohn's disease patients. Presented at: World Congress of Gastroenterology; October 13-18, 2017; Orlando, FL.

  5. 5.Shah JM, Omar E, Pai DR, Sood S. Cellular events and biomarkers of wound healing. Indian J Plast Surg. 2012;45(2):220-228.

  6. 6.Kelly OB, Silverberg MS, Dulai PD, et al. Development and validation of a multi-marker serum test for the assessment of mucosal healing in Crohn's disease patients. Presented at: World Congress of Gastroenterology; October 13-18, 2017; Orlando, FL.