PROMETHEUS® Monitr™ Crohn’s Disease Test

The serum test that gives the mucosa a voice

Measure and monitor mucosal healing status at any time in your Crohn’s disease patients with 1 simple serum test

Measure, monitor, and track endoscopic disease activity in your adult Crohn’s disease (CD) patients with 1 simple serum test

Improvement in mucosal damage provides an objective measure of therapeutic response in CD management.1 However, current assessment methods may not provide needed information, particularly when evaluating disease activity in difficult-to-reach locations to assess ileal disease.1-3

The PROMETHEUS® Monitr™ Crohn’s Disease Test is a laboratory-developed test that evaluates multiple markers of mucosal damage and repair processes, regardless of disease location.4 It applies a proprietary algorithm to 13 biomarkers to produce a quantitative Endoscopic Healing Index (EHI) Score—ranging from 0 to 100—to aid in distinguishing endoscopic remission from active disease in adult CD patients.

Comprehensive assessment

Incorporates a panel of biomarkers that are associated with mucosal homeostasis, mucosal damage, and wound healing.4,5


Quantitative test results

Provides an EHI Score to help distinguish remission from active disease.


Proven test performance

Identified optimal thresholds to maximize sensitivity and specificity for ruling in and ruling out endoscopically active disease.4,*



*Endoscopy-paired serum samples from 195 adult CD patients at a US-based tertiary care center were used to validate the Monitr Endoscopic Healing Index. Biomarker expression was modeled against endoscopic scoring with Crohn’s Disease Endoscopic Index of Severity (CDEIS) or Simple Endoscopic Score for Crohn’s Disease (SES-CD).4

  1. 1.De Cruz P, Kamm MA, Prideaux L, Allen PB, Moore G. Mucosal healing in Crohn’s disease: a systematic review. Inflamm Bowel Dis. 2013;19(2):429-444.

  2. 2.Shah SC, Colombel JF, Sands BE, Narula N. Systematic review with meta-analysis: mucosal healing is associated with improved long-term outcomes in Crohn’s disease. Aliment Pharmacol Ther. 2016;43(3):317-333.

  3. 3.Bryant RV, Winer S, Travis SP, Riddell RH. Systematic review: histological remission in inflammatory bowel disease. Is ‘complete’ remission the new treatment paradigm? An IOIBD initiative. J Crohns Colitis. 2014;8(12):1582-1597.

  4. 4.D’Haens G, Kelly O, Battat R, et al. Development and validation of a test to monitor endoscopic activity in patients with Crohn’s disease based on serum levels of proteins. Gastroenterology. 2020;158(3):515-526.e10.

  5. 5.Shah JM, Omar E, Pai DR, Sood S. Cellular events and biomarkers of wound healing. Indian J Plast Surg. 2012;45(2):220-228.

Easy to order: Monitr™ Test Requisition Form. For assistance ordering, contact Client Services toll-free in the US at 888-423-5227 (Monday through Friday from 6 AM to 4:30 PM PT).