Clinical performance

Helps you assess Crohn's disease activity

The PROMETHEUS Monitr Crohn's Disease Test is a laboratory-developed test that demonstrated a 90% concordance rate with endoscopically visualized mucosal inflammation in a retrospective study where 748 serum samples from 396 adult Crohn's disease patients were analyzed.1


Additionally, Monitr also demonstrated 1,*:

  • 92% negative predictive value for identifying patients in remission or with mild endoscopic disease
  • 87% positive predictive value for identifying patients with endoscopic evidence of active disease
 

Monitr test performance1

In another study where 412 longitudinal serum samples from 118 adult Crohn's disease patients were collected at the time of or close to endoscopy, Monitr demonstrated the ability to assess the state of the intestinal mucosa in Crohn's disease patients regardless of disease location. This study validated the clinical utility of Monitr in measuring and monitoring mucosal healing status in adult Crohn's disease patients. 2,**

Monitr performance by Crohn's disease location2

*Remission was defined as CDEIS < 3 and mild endoscopic disease was defined as CDEIS 3-8. Endoscopic evidence of active disease was defined as CDEIS ≥ 3. Specimens that fell within Mucosal Healing Index (MHI) range 41-49 had an observed 78% probability of active disease.

**Endoscopic scoring was centrally read and mucosal healing was defined as the absence of visual endoscopic ulcers.

Easy to order: To request a Monitr Test Requisition Form, call Client Services toll-free in the U.S. at 888-423-5227 (Monday through Friday from 6 AM to 4:30 PM PST) or visit www.prometheuslabs.com.

References

References:
  1. 1.Kelly OB, Silverberg MS, Dulai PD, et al. Development and validation of a multi-marker serum test for the assessment of mucosal healing in Crohn’s disease patients. Presented at: World Congress of Gastroenterology; October 13-18, 2017; Orlando, FL.

  2. 2.Vermeire S, D’Haens G, Hale M, et al. A novel serum test to describe the mucosal healing state by disease location in Crohn’s disease patients. Presented at: World Congress of Gastroenterology; October 13-18, 2017; Orlando, FL.